The β-carboline Harmine Induces Actin Dynamic Remodeling and Abrogates the Malignant Phenotype in Tumorigenic Cells
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چکیده
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Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin
Despite being an invaluable chemotherapeutic agent for several types of cancer, the clinical utility of doxorubicin is hampered by its age-related and dose-dependent cardiotoxicity. Co-administration of dexrazoxane as a cardioprotective agent has been proposed, however recent studies suggest that it attenuates doxorubicin-induced antitumor activity. Since compounds of natural origin present a r...
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ژورنال
عنوان ژورنال: Cells
سال: 2020
ISSN: 2073-4409
DOI: 10.3390/cells9051168